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2024                                                                                                                                                                                                   2022

Our review article is published in Frontiers in Nutrition "Beneficial effects of seaweed-derived components on metabolic syndrome via gut microbiota modulation"
Metabolic syndrome, linked to conditions like obesity and diabetes, can be influenced by gut microbiota, which is impacted by diet. Recent studies indicate that seaweed in the diet can help prevent this syndrome through gut microbiota regulation. Seaweed-based components can adjust the balance of beneficial and harmful bacteria in the gut, potentially improving gut health, reducing inflammation, and impacting metabolism. While promising, these findings need validation through more extensive animal studies and human clinical trials.

Special Issue

Published "Paraburkholderia sabiae administration alters zebrafish anxiety-like behavior via gut microbial taurine metabolism". 
Interventions to the gut microbiome manipulate the gut–brain axis and could be useful in the treatment of anxiety and depression. In this study, we demonstrated that administration of the bacterium Paraburkholderia sabiae reduces anxiety-like behavior in adult zebrafish. P. sabiae administration increased the diversity of the zebrafish gut microbiome. Linear discriminant analysis Effect Size (LEfSe) analysis revealed that the populations of Actinomycetales including Nocardiaceae, Nocardia, Gordoniaceae, Gordonia, Nakamurellaceae, and Aeromonadaceae were reduced, whereas those of Rhizobiales including Xanthobacteraceae, Bradyrhizobiaceae, Rhodospirillaceae, and Pirellulaceae were increased in the gut microbiome. Functional analysis using Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt2) predicted that P. sabiae administration altered taurine metabolism in the zebrafish gut, and we demonstrated that P. sabiae administration increased the taurine concentration in the brain. Since taurine functions as an antidepressant neurotransmitter in vertebrates, our results suggest that P. sabiae could improve anxiety-like behavior in zebrafish via the gut-brain axis.

Special Issue

2-174 Edobashi, Tsu, Mie, 5148572, Japan


Yasuhito Shimada, MD, PhD.
Phone: +81 (0) 59 231 5384