Bone aging
As society continues to age, "how to age healthily" has become an important issue. In response to this challenge, we are conducting research using zebrafish. We reported that the bone density of zebrafish vertebral bones decreases with aging using CT, but this model was not suitable for drug testing due to the labor and time involved. Therefore, we propose a model of osteoporosis using zebrafish scales. The regeneration of zebrafish scales is composed of a balance between osteoblasts and osteoclasts, and administering adrenal cortical steroid hormones that induce osteoporosis makes osteoclasts dominant and regeneration fails. Using this model, we discovered that 10-gingerol, a new component derived from ginger, inhibits osteoclast differentiation.
